A hybrid AI/physics-based platform for enhanced, full-length mRNA design
Codonscope generates full-length mRNA sequences with increased stability, translation efficiency and protein yield, leading to next generation mRNA therapeutics.
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Research & Technology
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Beyond Codon Optimization
Codonscope explores the vast mRNA sequence space to design coding sequences that go far beyond traditional codon optimization, resulting in higher and prolonged protein expression across cell types.
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AI-Driven Stability & Expression
Our platform intelligently optimizes mRNA for both translation efficiency and structural stability — increasing resistance to degradation and boosting protein output, even in immunocompetent cells.
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Integrated Regulatory Engineering
Unlike conventional tools, Codonscope co-designs the 5’UTR, coding sequence, and 3’UTR to generate mRNAs with superior thermodynamic properties and functional performance.
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Core Capabilities & Highlights
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Protein Expression Boost
Codonscope-designed mRNAs showed up to 8× more protein output compared to wild-type sequences in lab validation.
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Chimeric Antigen Receptors
Codonscope-optimized CAR mRNAs resulted in 2× more protein and 2× more CAR-expressing cells at 48h post-transfection.
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AI-Powered Design Engine
Our models generate mRNA sequence within minutes or hours depending on sequence length, identifying designs with superior stability and translation.
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Flexible Delivery Options
We deliver optimized constructs as plasmids, IVT mRNA, or LNP formulations — tailored to your research workflow.
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Press
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